Neuroscientists are beginning to acknowledge that, even within restricted neuroscientific research domains, no individual is smart enough to remember, evaluate, and synthesize the existing literature.
As an illustration of the problem, a search using PubMed for the number of articles published in 2006 matching the term "hippocampus" (a neuroanatomical structure) yields 5,042 published articles. Even if a person could read a page per minute and each article were only 10 pages, it would take 840 hours to read the 2006 hippocampus-related literature. That doesn't leave much time for conducting experiments (or reading the 69,327 hippocampus-related articles published prior to 2006).
The main purpose of the BrainFrame project is to create a new tool that employs severeal technologies to improve knowledge management within the neurosciences.